A multidisciplinary approach to understand the link between stroke and Alzheimer’s

The Horizon 2020 project CoSTREAM aimed to improve our understanding of the co-occurrence of stroke and Alzheimer’s disease. It has long been known that both diseases share underlying causes, but their exact interaction or link is not fully understood. CoSTREAM combines multiple factors to identify and investigate these common mechanisms, ranging from genetics and metabolomics, to brain structure and function. The project builds upon large data sets on both diseases, with follow-up studies performed up to 25 years. In the end, CoSTREAM will lead to increased knowledge about shared pathways, and can lead to new therapeutic approaches.

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News Archive

Common mechanisms and pathways in stroke and Alzheimer's disease

CoSTREAM is a five-year research project combining epidemiology, genetics, metabolomics, radiology and neurology. We will use comprehensive preclinical knowledge and clinical data to discover new molecular pathways that explain the co-occurrence of stroke and Alzheimer's disease, and determine how these relate to structural and functional pathology on magnetic resonance imaging (MRI) and to molecular imaging biomarkers on positron emission tomography (PET). Furthermore, we will investigate shared and disease-unique compensatory mechanisms and develop new treatment strategies targeting areas of interaction between the two diseases.

Frequently Asked Questions

We answered some of the most frequently asked questions about the project, and stroke and Alzheimer’s disease.

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Work packages

The CoSTREAM project is divided into seven work packages with their own theme, across three phases focused on finding common causes, shared pathways and the translation of results.

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We're making our research findings available free of charge for readers and are providing open access to published papers and reports.

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Our multidisciplinary consortium combines the expertise of 11 partners from 7 countries. It includes major universities, research institutes and industry partners. To find out more about our consortium and its scientists, click on the country flags on the map below and the individual partner logos to the right.

CoSTREAM will increase knowledge of common causes between stroke and Alzheimer's and lead to better strategies in clinical and public health care

Find all our press publications, media, and our research results here.

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Our scientific publications are published free of any restrictions on access. View our scientific publications and our public reports.

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Press and Media

Download all our promotional materials, such as flyers and folders, and read our press releases.

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If you have additional questions, or would like to receive more in-depth information on CoSTREAM, don’t hesitate get in touch with us!

Cornelia van Duijn
Project coordinator

Cornelia van Duijn is a professor of Genetic Epidemiology at Erasmus University Medical Center. She is the project coordinator for CoSTREAM and leads the project in scientific aspects. She also is the principal investigator for three large-scale population studies, including the Rotterdam Study. Her work focuses on –omics research in neurodegenerative disorders.

Peter Gordebeke
Project manager

Peter Gordebeke is a project manager at the European Institute for Biomedical Imaging Research, and leads the project management of CoSTREAM. He has done research in RNA biology in both academic and industry settings, and has past experience in project management of clinical studies, and FP7-funded research.