Clinical Prediction
Work Package 5

The project's fifth Work Package integrated results from the four previous Work Packages by assessing the joint predictive value and clinical utility of genetic, metabolomic, imaging, and compensatory factors for stroke and Alzheimer's disease. Genetic, metabolomic, imaging, and compensatory mechanisms from Work Package 1 to 4 and markers thereof were validated in independent studies for their association with stroke and Alzheimer's disease. A joint risk score for stroke and Alzheimer's disease based on biomarkers was developed, which was then implemented in a prediction tool.