The Horizon 2020 project CoSTREAM aimed to improve our understanding of the co-occurrence of stroke and Alzheimer’s disease. It has long been known that both diseases share underlying causes, but their exact interaction or link is not fully understood. CoSTREAM combines multiple factors to identify and investigate these common mechanisms, ranging from genetics and metabolomics, to brain structure and function. The project builds upon large data sets on both diseases, with follow-up studies performed up to 25 years. In the end, CoSTREAM will lead to increased knowledge about shared pathways, and can lead to new therapeutic approaches.
CoSTREAM is a five-year research project combining epidemiology, genetics, metabolomics, radiology and neurology. We will use comprehensive preclinical knowledge and clinical data to discover new molecular pathways that explain the co-occurrence of stroke and Alzheimer's disease, and determine how these relate to structural and functional pathology on magnetic resonance imaging (MRI) and to molecular imaging biomarkers on positron emission tomography (PET). Furthermore, we will investigate shared and disease-unique compensatory mechanisms and develop new treatment strategies targeting areas of interaction between the two diseases.
We answered some of the most frequently asked questions about the project, and stroke and Alzheimer’s disease.
The CoSTREAM project is divided into seven work packages with their own theme, across three phases focused on finding common causes, shared pathways and the translation of results.
We're making our research findings available free of charge for readers and are providing open access to published papers and reports.
Our multidisciplinary consortium combines the expertise of 11 partners from 7 countries. It includes major universities, research institutes and industry partners. To find out more about our consortium and its scientists, click on the country flags on the map below and the individual partner logos to the right.
CoSTREAM will increase knowledge of common causes between stroke and Alzheimer's and lead to better strategies in clinical and public health care
If you have additional questions, or would like to receive more in-depth information on CoSTREAM, don’t hesitate get in touch with us!
Cornelia van Duijn is a professor of Genetic Epidemiology at Erasmus University Medical Center. She is the project coordinator for CoSTREAM and leads the project in scientific aspects. She also is the principal investigator for three large-scale population studies, including the Rotterdam Study. Her work focuses on –omics research in neurodegenerative disorders.
Peter Gordebeke is a project manager at the European Institute for Biomedical Imaging Research, and leads the project management of CoSTREAM. He has done research in RNA biology in both academic and industry settings, and has past experience in project management of clinical studies, and FP7-funded research.